Henriette Pilegaard

This study shows that Rac1 deficiency in muscle reduces mitochondrial function and fatty acid metabolism, leading to muscle wasting and highlights potential therapeutic targets for age-related muscle decline.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

This study investigates the AMPKgamma3 R225W mutation in human and mouse skeletal muscle, finding no increase in basal activity or glycogen levels, but loss of activation by AICAR/muscle contraction.