SUMO paralogues differentially affect phase separation and aggregation of intrinsically disordered proteins
Philipp Christian Schönberger, Supriyo Naskar, Oliver Ordowski, Joshua Vollrath, Jia-Xuan Chen, Martin M. Möckel, Márton Gelléri, Christian Renz, Julian D. Langer, Kurt Kremer, Oleksandra Kukharenko, Helle D. Ulrich
This study shows SUMO1 and SUMO2 differentially regulate TDP-43 phase separation and aggregation, with SUMO1 inhibiting and SUMO2 promoting liquid-like states that prevent aggregation.
bioRxiv · May 13, 2026 · PreprintMolecular Biology