Molecular BiologybioRxivPreprint
SUMO paralogues differentially affect phase separation and aggregation of intrinsically disordered proteins
Philipp Christian Schönberger, Supriyo Naskar, Oliver Ordowski…·Helle D. Ulrich
This study shows SUMO1 and SUMO2 differentially regulate TDP-43 phase separation and aggregation, with SUMO1 inhibiting and SUMO2 promoting liquid-like states that prevent aggregation.
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