Martin M. Möckel

A Phosphorylation-Induced Micellization switch in the low complexity domain of TDP-43

This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.

SUMO paralogues differentially affect phase separation and aggregation of intrinsically disordered proteins

This study shows SUMO1 and SUMO2 differentially regulate TDP-43 phase separation and aggregation, with SUMO1 inhibiting and SUMO2 promoting liquid-like states that prevent aggregation.

PARP1 Writes N3-Cytidine ADP-Ribosylation in DNA

This study identifies PARP1's ability to ADP-ribosylate N3-deoxycytidine in ssDNA, leading to deamination products detectable by LC-MS/MS.

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.