Christian Renz

The paper shows that branching of polyubiquitin chains on PCNA, mediated by UBE2K, orchestrates the DNA replication stress response by promoting re-priming of stalled forks and requiring BRCA1-dependent repair.

This study identifies how DNA and ubiquitin relieve autoinhibition in SPRTN, enabling its protease activity through conformational changes.

This study shows SUMO1 and SUMO2 differentially regulate TDP-43 phase separation and aggregation, with SUMO1 inhibiting and SUMO2 promoting liquid-like states that prevent aggregation.

This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.

This study identifies a family of FYVE-type-RING finger proteins as E3 ligases that cooperate with Ubc13-Mms2 in K63-polyubiquitylation at internal membranes across species.

The paper identifies PETISCO as a novel protein complex essential for 21U RNA biogenesis and embryonic viability in C. elegans, revealing its distinct roles from PID-1.

The paper identifies GTSF-1 as a protein required for the formation of an RNA-dependent RNA Polymerase complex in C. elegans, which is essential for 26G-RNA generation.