Helle D. Ulrich

The paper shows that branching of polyubiquitin chains on PCNA, mediated by UBE2K, orchestrates the DNA replication stress response by promoting re-priming of stalled forks and requiring BRCA1-dependent repair.

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

The paper identifies a DNA-bound intermediate during MCM2-7 helicase activation and shows how DNA unwinding is coupled to helicase complex disassembly and DNA exit.

This study identifies how DNA and ubiquitin relieve autoinhibition in SPRTN, enabling its protease activity through conformational changes.

This study shows SUMO1 and SUMO2 differentially regulate TDP-43 phase separation and aggregation, with SUMO1 inhibiting and SUMO2 promoting liquid-like states that prevent aggregation.

RepliCNN predicts DNA replication timing and related features from strand-specific 3' DNA end sequencing data with high accuracy.

This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.

This study examines how the timing of lesion bypass during DNA replication affects mutagenesis, showing that TLS at certain lesions occurs post-replicatively and competes with DA, reducing mutagenicity.

The paper identifies TelAP2 as an interacting partner of TelAP1 in the telomere complex of Trypanosoma brucei and shows that TelAP1 requires this interaction to associate with telomeric proteins.

The paper investigates the differential regulation of RNase H1 and H2 in yeast, showing RNase H2 is cell cycle-dependent while RNase H1 acts independently of cell cycle stage.

This study identifies a family of FYVE-type-RING finger proteins as E3 ligases that cooperate with Ubc13-Mms2 in K63-polyubiquitylation at internal membranes across species.

The paper identifies PETISCO as a novel protein complex essential for 21U RNA biogenesis and embryonic viability in C. elegans, revealing its distinct roles from PID-1.

The paper identifies GTSF-1 as a protein required for the formation of an RNA-dependent RNA Polymerase complex in C. elegans, which is essential for 26G-RNA generation.