BioengineeringACS NanoPeer-reviewed
2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticles
Anjaneyulu Dirisala, Bhaskar Chatterjee, Le Bui Thao Nguyen…·Satoshi Uchida
This paper demonstrates that 2-arm-PEG-oligocations transiently shield liver sinusoids to reduce off-target hepatic mRNA expression and improve iLNP delivery to spleen and tumors.