David J. Kelvin

Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins

This paper develops a broad-spectrum multiepitope vaccine for bluetongue virus targeting conserved T cell epitopes in structural proteins, showing strong binding and potential for inducing immune responses.

MPXV Clade IIb virus infection in mice leads to prolonged viral replication, macrophage infiltration, and decreased spermatogenesis in the testes.

Immuno-informatics Study Identifies Conserved T Cell Epitopes in Non-structural Proteins of Bluetongue Virus Serotypes: Formulation of Computationally Optimized Next-Generation Broad-spectrum Multiepitope Vaccine

The paper identifies conserved T cell epitopes in Bluetongue Virus non-structural proteins and evaluates their potential as a broad-spectrum vaccine using computational methods.

Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics

This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.

PoxiPred: An artificial intelligence-based method for the prediction of potential antigens and epitopes to accelerate vaccine development efforts against poxviruses.

PoxiPred predicts potential antigens and T-cell epitopes for poxviruses using an AI-based tool trained on viral proteomes.