DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma
Tao Lin, Chenjun Huang, Chenhao Tong…·Honglei Weng
The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.