Mia Madel Alfajaro

MPXV Clade IIb virus infection in mice leads to prolonged viral replication, macrophage infiltration, and decreased spermatogenesis in the testes.

HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro

This study identifies merafloxacin as a -1 PRF inhibitor that impedes SARS-CoV-2 replication in vitro.

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium

Time-course single-cell RNA sequencing of infected human bronchial epithelial cultures reports ciliated cells as a major target, with tropism later widening to basal and club cells.