Brittany S. Pate

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

This study investigates the impact of early locus coeruleus lesions in TgF344-AD rats and finds that LC lesions and AD genotype rarely interact to worsen deficits or neuropathology.

This study uses chemogenetics to inhibit microglia in the locus coeruleus of female rats, showing reduced inflammation and hypervigilant behavior in response to social stress.

This study shows that blocking estrogen receptor beta in the central amygdala prevents stress-induced anxiety and depressive behaviors in female rats exposed to repeated social stress.

This study shows that microglia in the locus coeruleus of female rats influence hypervigilant responses to social stress, with site-specific microglia depletion reducing stress-induced behaviors.