This study investigates the impact of early locus coeruleus lesions in TgF344-AD rats and finds that LC lesions and AD genotype rarely interact to worsen deficits or neuropathology.

2 citationstop 4%

ratexperimental assay

𝕏 PostBluesky

NeuroscienceImaging NeurosciencePeer-reviewedJan 1, 2024

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats

Nmachi Anumba, Michael A. Kelberman, Wen‐Ju Pan…·Shella Dawn Keilholz

This study investigates how optogenetic stimulation of the locus coeruleus affects global spatiotemporal patterns in rats using resting-state fMRI.

5 citations

ratimaging

𝕏 PostBluesky

NeurosciencebioRxivNov 15, 2022

Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimers disease

Michael A. Kelberman, Jacki M. Rorabaugh, Claire R. Anderson…·David Weinshenker

This study examines age-related changes in locus coeruleus firing in a transgenic rat model of Alzheimer's disease, finding age-dependent hypoactivity and hyperactivity in response to stimuli.

48 citationstop 3%

ratexperimental assay

𝕏 PostBluesky