Todd Anthony Aguilera

Resolving phenotyping discordance with SPACEMAP, an integrated machine learning framework

SPACEMAP is a machine learning framework for multiplex imaging analysis that resolves phenotyping discordance by integrating multiple classification methods.

Immune stromal components impede biological effectiveness of carbon ion therapy in a preclinical model of pancreatic ductal adenocarcinoma

This study evaluates carbon ion therapy's effectiveness in pancreatic ductal adenocarcinoma, finding that immune stromal components reduce its efficacy in vivo compared to in vitro results.

Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer

This study identifies PDAC cell lines defective in homologous recombination or with high genomic instability as more responsive to carbon ion radiotherapy, suggesting potential for targeted therapy.