ImmunologySciencePeer-reviewed
The anti-inflammatory activity of IgG requires the co-engagement of types I and II Fc receptors
Andrew Jones, Alessandra E. Marino, Tetyana Martynyuk…·Jeffrey V. Ravetch
This study shows that IgG's anti-inflammatory activity depends on the interaction between Fc{gamma}RIIB and DC-SIGN, and engineering sialylated IgG1 enhances its potency in treating autoimmune diseases.
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