Jeffrey V. Ravetch

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

This study shows that IgG's anti-inflammatory activity depends on the interaction between Fc{gamma}RIIB and DC-SIGN, and engineering sialylated IgG1 enhances its potency in treating autoimmune diseases.