Aslı Yıldırım

An integrated view of the structure and function of the human 4D nucleome

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

Conformational analysis of chromosome structures reveals vital role of chromosome morphology in gene function

The paper introduces a dimensionality reduction method to classify single-cell chromosome structures into conformational clusters, revealing that distinct morphologies influence gene function through subnuclear positioning.

Genome wide profiling of histone H3 lysine 4 methylation during the Chlamydomonas cell cycle reveals stable and dynamic properties of lysine 4 trimethylation at gene promoters and near ubiquitous lysine 4 monomethylation

This study uses ChIP-Seq to profile H3K4 methylation across the Chlamydomonas cell cycle, revealing distinct patterns of mono- and trimethylation at gene promoters and their relationship to gene expression.

Population-based structure modeling reveals key roles of nuclear microenvironment in gene functions

The paper uses population-based modeling of Hi-C data to analyze the nuclear microenvironment's role in gene function, revealing structural variability and functional heterogeneity.