This study finds ADHD is genetically more closely linked to neurodevelopmental disorders than externalizing or internalizing disorders after accounting for a general psychopathology factor.

The British Journal of Psychiatry · Sep 7, 2020Peer-reviewedGenetic & Genomic Medicine

Machine-Learning Prediction of Comorbid Substance Use Disorders in ADHD Youth Using Swedish Registry Data

Yanli Zhang‐James, Qi Chen, Ralf Kuja‐Halkola, Paul Lichtenstein, Henrik Larsson, Stephen V. Faraone

This study uses Swedish registry data to predict substance use disorders in ADHD youth with machine learning models, achieving moderate accuracy even without prior SUD diagnosis.

Journal of Child Psychology and Psychiatry · Apr 1, 2020Peer-reviewedNeuroscience

Sex differences in brain structure: An autism twin study on restricted and repetitive behaviors

Annelies van’t Westeinde, Élodie Cauvet, Roberto Toro, Ralf Kuja‐Halkola, Janina Neufeld, Katell Mevel, Sven Bölte

Molecular Autism · Dec 31, 2019Peer-reviewedNeuroscience

Sex differences along the Autism Continuum: A twin study of brain structure

Élodie Cauvet, Annelies van’t Westeinde, Roberto Toro, Ralf Kuja‐Halkola, Janina Neufeld, Katell Mevel, Sven Bölte

This study investigates sex differences in brain structure related to autism traits using twin data, finding that females show greater environmental impact on brain morphology compared to males.

Cerebral Cortex · Nov 15, 2018Peer-reviewedNeuroscience

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology

Isabell Brikell, Henrik Larsson, Yi Lu, Erik Pettersson, Qi Chen, Ralf Kuja‐Halkola, Robert Karlsson, Benjamin B. Lahey, Paul Lichtenstein, Joanna Martin

This study evaluates ADHD genetic risk variants' association with general psychopathology and specific neurodevelopmental traits, finding general pleiotropy and a specific link to hyperactivity/impulsivity.

Molecular Psychiatry · Jun 22, 2018Peer-reviewedGenetics