Sven Bölte

Functional connectivity in infants' visual cortex: Links to motion processing and autism

The paper examines altered visual cortical functional connectivity in 5-month-old infants linked to autism symptoms and motion processing.

LEAP-InovAND a multiscale resource to explore genetics, brain imaging and clinical data in autism

The paper introduces a multiscale resource integrating genetics, brain imaging, and clinical data from autistic individuals and their relatives to explore genetic and neurobiological patterns in autism.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

European Autism GEnomics Registry (EAGER): Protocol for a multicentre cohort study and registry

EAGER establishes a registry of autistic individuals and those with rare genetic conditions for genomic and phenotypic research, aiming to improve clinical trials and health outcomes through data sharing.

Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

Learning about neurodiversity from parents - auditory gestalt perception of prelinguistic vocalisations

This study examines how parents of children with Rett syndrome perceive prelinguistic vocalizations, finding they can distinguish RTT vocalizations from typically developing ones, even when the RTT vocalizations are considered inconspicuous by experts.

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

The paper investigates the relationship between glutamate and GABA gene-sets, autism symptoms, and cortical thickness using data from the EU-AIMS LEAP cohort.

Patterns of connectome variability in autism across five functional activation tasks. Findings from the LEAP project

The paper identifies patterns of neural variability in autism using fMRI across tasks, finding greater global connectivity deviations and similar spatial patterns in autistic individuals compared to controls.

Autism is associated with inter-individual variations of gray and white matter morphology

The paper identifies a multimodal brain pattern associated with autism by integrating gray and white matter morphology data and linking it to clinical symptoms.

Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

The paper examines hemispheric asymmetry in structural covariance networks in ASD across 43 datasets, finding altered topological features in specific brain regions.

Rare variants in the outcome of social skills group training for autism

The paper uses exome sequencing to identify genetic variants associated with response to social skills training in autistic individuals, finding that rare variants may reduce intervention effectiveness.

Babytwins Study Sweden (BATSS): A multi-method infant twin study of genetic and environmental factors influencing infant brain and behavioral development

The paper describes the Babytwins Study Sweden (BATSS), a longitudinal twin study combining EEG, eye tracking, genetics, and behavioral assessments to investigate genetic and environmental influences on infant brain and behavioral development.

The influence of common polygenic risk and gene sets on social skills group training response in autism spectrum disorder

Presynaptic dysfunction in CASK-related neurodevelopmental disorders

This study investigates the effects of CASK mutations in human neurons derived from iPSCs, showing reduced CASK protein and altered presynaptic development, with implications for excitatory-inhibitory balance.

Atypical brain asymmetry in autism - a candidate for clinically meaningful stratification

The paper identifies atypical brain asymmetry in autism as a potential neurophenotype for stratification, showing individualized patterns linked to symptom severity and language delay.

Attenuated Anticipation of Social and Monetary Rewards in Autism Spectrum Disorders

This study investigates reward processing in autism spectrum disorder (ASD) and finds generalized hypoactivity in the ventral striatum during anticipation of both social and monetary rewards.

Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms

The paper develops a phenotypic stratification model to predict autism subtypes based on SC-RRB balance and applies it to fMRI data, identifying subtype-specific neural circuitry and gene expression patterns.

Sex differences in brain structure: An autism twin study on restricted and repetitive behaviors

Association Between Rare Copy Number Variation and Response to Social Skills Training in Autism Spectrum Disorder

This study investigates whether rare copy number variations (CNVs) moderate response to social skills training in ASD, finding that large CNVs are associated with worse outcomes while small CNVs show mixed effects.

Dissecting the heterogeneous cortical anatomy of autism spectrum disorder using normative models

This study uses normative models to analyze cortical thickness deviations in ASD, finding individualized patterns rather than common case-control differences.

Sex differences along the Autism Continuum: A twin study of brain structure

This study investigates sex differences in brain structure related to autism traits using twin data, finding that females show greater environmental impact on brain morphology compared to males.

Copy Number Variation Analysis of 100 Twin Pairs Enriched for Neurodevelopmental Disorders

The paper analyzes copy number variations in 100 twin pairs enriched for neurodevelopmental disorders, finding no postzygotic de novo CNVs but higher rates of CNVs overlapping nervous system genes in discordant pairs.