Hematopoiesis at single cell resolution spanning human development and maturation
Hojun Li, Jideofor Ezike, Anton Afanassiev, Laura Greenstreet, Stephen X. Zhang, Jennifer Whangbo, Vincent L. Butty, Enrico Moiso, Guinevere G. Connelly, Vivian Morris, Dahai Wang, George Q. Daley, Salil Garg, Stella T. Chou, Aviv Regev, , R. Grant Rowe
The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.
bioRxiv · Aug 25, 2021 · PreprintDevelopmental Biology