Benjamin Dekel

This study develops stem cell-based embryo models for sheep and pig, recapitulating post-gastrulation development with neuronal and mesodermal structures.

The paper uses optical genome and epigenome mapping to identify somatic alterations in early-stage clear cell renal cell carcinoma, revealing both known and novel genomic and epigenomic changes.

The paper compares optical genome mapping and nanopore sequencing for structural and epigenetic analysis of a kidney tumor, highlighting their strengths in variant detection and epigenetic profiling.

The paper uses single-cell RNA sequencing to study mRNA splice isoform switching during mouse kidney development and identifies potential splicing regulators.

The paper identifies splice isoform switching during human kidney development and links it to Wilms tumor by analyzing RNA sequencing data from fetal kidney stages and tumor models.