Naomi Pode‐Shakked

This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.

The paper investigates Notch signaling's role in nephron segmentation, finding it promotes proximal fate selection while not affecting distal fate in mouse and human kidney development.

The paper uses single-cell RNA sequencing to study mRNA splice isoform switching during mouse kidney development and identifies potential splicing regulators.

The paper identifies splice isoform switching during human kidney development and links it to Wilms tumor by analyzing RNA sequencing data from fetal kidney stages and tumor models.