Mathias V. Schmidt

This study investigates how early life stress affects brain function and behavior in mice, revealing sex-specific differences in neurobiological outcomes.

This study shows that inhibiting FKBP51 with SAFit2 prevents social deficits caused by early life adversity in mice.

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

The paper introduces DeepOF, an open-source tool for analyzing social behavior in mice, and finds it detects distinct stress-induced social behavioral patterns.

The paper introduces DiffBrainNet, a framework combining differential expression and network analysis to study glucocorticoid responses in mouse brain regions, revealing gene-level and network-level insights.

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

This study shows that in mice, pre-stress social dominance interacts with sex to influence chronic stress outcomes, with males and females showing opposite behavioral responses to stress.

This paper investigates how m6A RNA methylation in the brain is regulated by stress and shows its role in fear memory, transcriptome response, and synaptic plasticity, with implications for stress-related disorders.