This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

Communications Biology · Dec 19, 2024Peer-reviewedAnimal Behavior & Cognition

Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Joeri Bordes, Lucas Miranda, Maya Reinhardt, Sowmya V. Narayan, Jakob Hartmann, Emily L. Newman, Lea M. Brix, Lotte van Doeselaar, Clara Engelhardt, Larissa J. Dillmann, Shiladitya Mitra, Kerry James Ressler, Benno Pütz, Felix V. Agakov, Bertram Müller‐Myhsok, Mathias V. Schmidt

The paper introduces DeepOF, an open-source tool for analyzing social behavior in mice, and finds it detects distinct stress-induced social behavioral patterns.

Nature Communications · Jul 18, 2023Peer-reviewedNeuroscience

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

Alexander S. Häusl, Thomas Bajaj, Lea M. Brix, Max L. Pöhlmann, Kathrin Hafner, Meri De Angelis, Joachim Nagler, Frederik Dethloff, Georgia Balsevich, Karl‐Werner Schramm, Patrick Giavalisco, Alon Chen, Mathias V. Schmidt, Nils C. Gassen

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

Science Advances · Mar 9, 2022Peer-reviewedNeuroscience

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

Alexander S. Häusl, Lea M. Brix, Jakob Hartmann, Max L. Pöhlmann, Juan Pablo López, Danusa Menegaz, Elena Brivio, Clara Engelhardt, Simone Roeh, Thomas Bajaj, Lisa Rudolph, Rainer Stoffel, Kathrin Hafner, Hannah M. Goss, Johannes M. H. M. Reul, , Mathias V. Schmidt

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

Molecular Psychiatry · Mar 1, 2021Peer-reviewedNeuroscience