Nils C. Gassen

In vitro programming and pseudounipolarization of human iPSC-derived sensory neurons

This study demonstrates the generation of functional human sensory neurons from iPSCs using NBI factors, showing their electrophysiological properties and disease relevance.

Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder

This study identifies DNA methylation changes over time during antidepressant treatment in MDD, linking them to neuroplasticity and inflammation, and shows differences between responders and non-responders.

Spermidine alleviates depression via control of the stress response

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies

This study investigates the differential dynamics and roles of FKBP51 isoforms in response to glucocorticoids using in vitro models and human blood cells, highlighting their distinct functions and implications for targeted therapies.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone- Mediated Orexigenic Feeding in Mice

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

Rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) targets glucocorticoid receptor signaling: a longitudinal cerebrospinal fluid proteome study

This study identifies HNK's mechanism of action by analyzing CSF proteome changes, showing its impact on glucocorticoid receptor signaling and potential upstream regulators.

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neurons

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

Stress-primed secretory autophagy drives extracellular BDNF maturation

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.