Author

Hugo Daniel Luján

Universidad Católica de CórdobaORCID 0000-0002-3797-8315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:deconvolution· 1 Approach:experimental assay· 1

Frequent Co-Authors

Elmer A. FernándeziD· 2 shared María Romina GirottiiD· 2 shared Aude BelbézieriD· 1 shared Bertrand BellieriD· 1 shared Darío RochaiD· 1 shared David KlatzmanniD· 1 shared Florencia VeigasiD· 1 shared Gabriel A. RabinovichiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBioinformatics

Elmer A. FernándezORCID

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3 papers

Recent·Most cited

Expression of IL-1R2 by Tfr prevents their IL-1-dependent proliferation and the exacerbation of allergy

Paul Engeroff, Aude Belbézier, Romain Vaineau, Gwladys Fourcade, Hugo Daniel Luján, Bertrand Bellier, Stéphanie Graff‐Dubois, David Klatzmann

This study shows that IL-1R2 on Tfr cells prevents excessive activation and allergy by limiting IgE and promoting IgG responses.

Allergy · Dec 18, 2024Peer-reviewedImmunology

MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity

Guadalupe Nibeyro, María Romina Girotti, Laura Beatriz Prato, Gabriel Morón, Hugo Daniel Luján, Elmer A. Fernández

The paper benchmarks neoantigen immunogenicity predictors and finds that MHC-I binding affinity and its derived metrics are insufficient to predict immunogenicity or tumor neoantigen burden as biomarkers.

bioRxiv · Mar 14, 2022 · PreprintBioinformatics

MIXTURE: an improved algorithm for immune tumor microenvironment estimation based on gene expression data.

Elmer A. Fernández, Yamil Damian Mahmoud, Florencia Veigas, Darío Rocha, Mónica Balzarini, Hugo Daniel Luján, Gabriel A. Rabinovich, María Romina Girotti

MIXTURE improves immune tumor microenvironment estimation by reducing overestimation of cell-type counts and improving accuracy in bulk RNA data.

bioRxiv · Aug 7, 2019 · PreprintBioinformatics