Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease
Nikolay S. Markov, Anthony Joseph Esposito, Karolina J. Senkow, Maxwell J. Schleck, Luisa Cusick, Zhan Yu, Yuliana V. Sokolenko, Estefani Diaz, Emmy Jonasson, Suchitra Swaminathan, Ziyan Lu, Radmila A. Nafikova, Samuel W. Fenske, Elsie G. Bunyan, Xóchitl G. Pérez-Leonor, , Monique Hinchcliff
The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.
bioRxiv · Aug 7, 2025 · PreprintImmunology