Cara J. Gottardi

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

This study uses I2MS to analyze phosphorylation states of catenins in HEK cells, revealing their regulation by actomyosin contractility and identifying a phospho-code model for mechano-transduction.

This study shows that α-catenin phosphorylation, regulated by actomyosin contractility, is essential for epithelial barrier function through its interaction with Afadin.

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.

The paper shows that α-catenin phosphorylation during mitosis prevents apical rounding and epithelial barrier leak by strengthening cell-cell interactions.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.

This study shows that β-catenin signaling negatively regulates Arginase 1 expression in lung macrophages, which may influence lung repair after injury.