Annette S. Flozak

This study uses I2MS to analyze phosphorylation states of catenins in HEK cells, revealing their regulation by actomyosin contractility and identifying a phospho-code model for mechano-transduction.

This study shows that α-catenin phosphorylation, regulated by actomyosin contractility, is essential for epithelial barrier function through its interaction with Afadin.

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.

The paper shows that α-catenin phosphorylation during mitosis prevents apical rounding and epithelial barrier leak by strengthening cell-cell interactions.

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.

This study shows that β-catenin signaling negatively regulates Arginase 1 expression in lung macrophages, which may influence lung repair after injury.