Tamás Szommer

This study identifies distinct transcriptional states of T cells in draining lymph nodes after influenza vaccination in individuals with African or Asian ancestry using scRNA-seq.

This study examines immune responses in ancestrally diverse individuals after influenza vaccination, finding that draining lymph nodes show rapid activation and specific cellular changes.

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.