Fernando Gianfrancesco

This study shows ZNF687 regulates bone marrow myeloid progenitor dynamics and osteoclastogenesis, linking its loss to reduced osteoclast differentiation and increased trabecular bone mass in a mouse model.

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

The paper presents genomic data from a Late Epigravettian individual in Italy dated to 16,980-16,510 cal BP, showing genetic replacement associated with the emergence of Late Epigravettian culture, pushing back the spread of a Balkan/Anatolian genetic component by 3,000 years.