Author

Simon Gemble

Centre National de la Recherche ScientifiqueORCID 0000-0002-4351-7136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

Renata BastoiD· 3 shared Anne‐Sophie MacéiD· 2 shared Anthony Y. SimoniD· 2 shared Federica Scotto di CarloiD· 2 shared Audrey ForestiD· 1 shared C Verdel· 1 shared Chantal DesdouetsiD· 1 shared Clotilde CadartiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

Renata BastoORCID

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3 papers

Recent·Most cited

Whole genome duplication through mitotic slippage causes nuclear instability

Simon Gemble, Margot Budzyk, Anthony Y. Simon, Ruxandra A. Lambuta, Luca Nanni, Nicole Weiss, Audrey Forest, Yekaterina A. Miroshnikova, Federica Scotto di Carlo, Véronique Marthiens, C Verdel, Jing Fang, Chantal Desdouets, Sara A. Wickström, Giovanni Ciriello, , Renata Basto

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

The EMBO Journal · Sep 19, 2026Peer-reviewedCell Biology

Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer

Federica Scotto di Carlo, Sharon Russo, Simon Gemble, Noemi Vitale, Anne‐Sophie Macé, Iris Harmsen, Maria Assunta Borriello, Floris Foijer, Marcello Manfredi, Renata Basto, Fernando Gianfrancesco

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

bioRxiv · May 15, 2026 · PreprintCancer Biology

A novel mechanism for centrosome expulsion ensures metabolic activity in polyploid cells

Riham Salame, Simon Gemble, Anthony Y. Simon, Lin Jawish, Anne‐Sophie Macé, Ptissam Bergman, Graça Raposo, Clotilde Cadart, Renata Basto

The paper identifies a novel centrosome elimination mechanism in Drosophila polyploid cells that supports metabolic activity by preserving mitochondrial function.

bioRxiv · Aug 1, 2025 · PreprintCell Biology