Anne‐Sophie Macé

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

The paper shows keratin 5/14 intermediate filaments position melanin pigments near the nucleus to protect DNA from UV damage, using human keratinocyte models and imaging.

This paper introduces ExoDeepFinder, a deep learning method for detecting dynamic exocytosis events in TIRFM images, showing better performance and adaptability than conventional methods.

This study identifies a novel role for Gen nuclease in promoting polyploid cell proliferation unrelated to DNA repair, by influencing DNA replication rates in non-physiological polyploidy.

The paper identifies a novel centrosome elimination mechanism in Drosophila polyploid cells that supports metabolic activity by preserving mitochondrial function.

This study shows that biomechanical stress in embryonic neural progenitors affects mitotic fidelity through cortical actin and tension.

The paper identifies two translocation modes for human fetal neural stem cells, showing that interphasic somal translocation (IST) accounts for 85% of their movement during cortical colonization.

This study shows keratinocyte-derived extracellular vesicles regulate melanocyte dendrite formation, melanosome maturation, and pigment transfer, contributing to skin pigmentation and photoprotection.

The paper maps cell fate decisions in human developing neocortex progenitors, showing abundant direct neurogenesis bypassing intermediate progenitors.