Author
Children's Hospital of PhiladelphiaORCID 0000-0002-3857-6633Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jonathan Sussman, Derek A. Oldridge, Wenbao Yu…·Kai Tan
This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.
Ammar S. Naqvi, Patricia J. Sullivan, Ryan J. Corbett…·Jo Lynne Rokita
The paper analyzes splicing in 729 pediatric brain tumors, identifies splicing-defined subgroups, and highlights CLK1 exon 4 as an oncofetal event linked to tumor prognosis.
Priyanka D. Sehgal, Ammar S. Naqvi, Makenna Higgins…·Andrei Thomas‐Tikhonenko
The paper identifies a NRCAM proteoform with skipped microexons as a targetable surface antigen in pHGG and demonstrates its utility in immunotherapy.
Zhuangzhuang Geng, Eric K. Wafula, Ryan J. Corbett…·Jo Lynne Rokita
The paper introduces OpenPedCan, a harmonized multi-omic dataset of pediatric cancer patients, providing integrated genomic, transcriptomic, and proteomic data for research and clinical applications.
Joshua A. Shapiro, Krutika Satish Gaonkar, Stephanie J. Spielman…·Jaclyn Taroni
OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.