Wenbao Yu

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

SINBAD is a tool for processing and analyzing single-cell DNA methylation data, offering preprocessing, quality assessment, and analysis modules.

The paper identifies a pre-hematopoietic (pre-HE) stage in mouse embryos and shows RUNX1 regulates the transition to hemogenic endothelium, leading to distinct HSPC populations in intra-arterial clusters.

scATAC-pro is a software tool for processing, analyzing, and visualizing scCAS data, providing quality assessment and downstream analysis utilities.

The paper examines 3D genome organization, epigenome, and transcriptome changes in fetal and adult mouse HSCs, finding stage-specific chromatin interactions and transcription factor roles.