Author

M.E. Sharpe

Paul Scherrer InstituteORCID 0000-0002-3880-7438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Aina E. CoheniD· 1 shared Alexander DeitersiD· 1 shared Brisa Caroline Alves ChagasiD· 1 shared Daniel Calero· 1 shared Dennis P. StegmanniD· 1 shared Guillermo A. CaleroiD· 1 shared Guowu LiniD· 1 shared Igor V. KurnikoviD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aina E. CohenORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2025

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou…·Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

3 citations

humanstructural biology