Author

Guowu Lin

University of PittsburghORCID 0000-0002-0823-0105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aina E. CoheniD· 2 shared Guillermo A. CaleroiD· 2 shared Aaron S. BrewsteriD· 1 shared Alexander B. TayloriD· 1 shared Alexander DeitersiD· 1 shared Amy HenricksoniD· 1 shared Andrew Holmes· 1 shared Andrew P. HinckiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Aina E. CohenORCID

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3 papers

Recent·Most cited

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou, Ulises Santiago, Igor V. Kurnikov, Silvia Russi, Brisa Caroline Alves Chagas, M.E. Sharpe, Dennis P. Stegmann, Shannon A. Heinig, Rohan K. Goyal, Veerappan Nagarajan, Daniel Calero, Sandra Viviana Vergara, Alexander Deiters, , Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

bioRxiv · Aug 21, 2025 · PreprintCancer Biology

Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10

Tristin A. Schwartze, Stefanie A. Morosky, Teresa L. Rosato, Amy Henrickson, Guowu Lin, Cynthia S. Hinck, Alexander B. Taylor, Shaun K. Olsen, Guillermo A. Calero, Borries Demeler, Beth L. Roman, Andrew P. Hinck

This study investigates how BMP-9 and BMP-10 form disulfide bonds and dimers, showing that geometric strain, not cysteinylation, reduces dimerization propensity and that residue swaps can reverse this effect.

Journal of Molecular Biology · Jan 8, 2025Peer-reviewedMolecular Biology

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

Christopher O. Barnes, Ying Wu, Jinhu Song, Guowu Lin, Elizabeth L. Baxter, Aaron S. Brewster, Veeranagu Nagarajan, Andrew Holmes, Michael Soltis, Nicholas K. Sauter, Jinwoo Ahn, Aina E. Cohen, Guillermo Calero

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.

bioRxiv · Nov 29, 2018 · PreprintBiophysics