Author

Brisa Caroline Alves Chagas

University of PittsburghORCID 0000-0001-8975-0438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Aina E. CoheniD· 1 shared Alexander DeitersiD· 1 shared Daniel Calero· 1 shared Dennis P. StegmanniD· 1 shared Guillermo A. CaleroiD· 1 shared Guowu LiniD· 1 shared Igor V. KurnikoviD· 1 shared M.E. SharpeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Aina E. CohenORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou, Ulises Santiago, Igor V. Kurnikov, Silvia Russi, Brisa Caroline Alves Chagas, M.E. Sharpe, Dennis P. Stegmann, Shannon A. Heinig, Rohan K. Goyal, Veerappan Nagarajan, Daniel Calero, Sandra Viviana Vergara, Alexander Deiters, , Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

bioRxiv · Aug 21, 2025 · PreprintCancer Biology