Todd J. Herron

This study shows that PFOA exposure during cardiomyocyte differentiation alters gene expression and electrophysiological function in hiPSC-CM, with effects lasting after exposure stops.

The paper uses donor-matched iPSC-derived FAPs to show that T2D GWAS signals are enriched in adipogenic FAP subtypes under high-insulin exposure.

This study shows that diet-induced obesity paradoxically increases SERCA activity in atrial myocytes, contributing to atrial fibrillation through altered Ca2+ dynamics.

This study investigates the effects of the R403Q beta-myosin mutation on cardiac myocyte calcium homeostasis and contractility, finding increased intracellular calcium and hyper-contractility.

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

This study identifies 111 genetic loci and 163 risk variants associated with atrial fibrillation using a GWAS of over 1 million individuals.