ImmunologybioRxivPreprint
Cholesterol constrains pore formation by mammalian gasdermins
Yisha Liang, Isabella Rose Fraschilla, Sepideh Parvanian…·Charles Lee Evavold
This study identifies Rabgef1 as a regulator of gasdermin pore formation by controlling membrane cholesterol, showing cholesterol depletion restores pyroptosis in cancer cells and tumors.