Cholesterol constrains pore formation by mammalian gasdermins
Yisha Liang, Isabella Rose Fraschilla, Sepideh Parvanian, Makiko Hayashi, Emerson Glassey, Gema González-Rubio, Inga M. Spannaus, Victoria Andrade, Benjamin L. Allsup, Fan Fei, Bryan D. Bryson, Aaron G. Schmidt, Tyler Jacks, Christopher Garris, Charles Lee Evavold
This study identifies Rabgef1 as a regulator of gasdermin pore formation by controlling membrane cholesterol, showing cholesterol depletion restores pyroptosis in cancer cells and tumors.
bioRxiv · Oct 15, 2026 · PreprintImmunology