Yisha Liang

This study shows that oleic acid reduces NLRP3 inflammasome activity in macrophages, preventing their death and limiting psoriasis-like skin inflammation in mice.

This study identifies Rabgef1 as a regulator of gasdermin pore formation by controlling membrane cholesterol, showing cholesterol depletion restores pyroptosis in cancer cells and tumors.

This study compares the metabolic states of Mycobacterium tuberculosis in human and mouse macrophages, revealing species-specific lipid metabolism and identifying a barrier to lipid access in human macrophages.

This study identifies the DENV replicative-form dsRNA as the PAMP recognized by RIG-I and MDA5 to activate innate immunity against dengue virus.