Sandra Ritz

The role of the synaptic vesicle protein SV2A in regulating mitochondrial morphology and autophagy.

This paper identifies SV2A as a mitochondrial outer membrane protein that regulates mitochondrial morphology and autophagy through interactions with DRP1 and ATG9A.

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

This study identifies how GDAP1 loss of function disrupts actin signaling, leading to mitochondrial tubularity and metabolic changes in CMT4A.

NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

This study identifies NECAB2's role in an endosomal pathway for mitochondrial stress response and repair in striatal synapses, linking its loss to synaptic loss and behavioral deficits.