Targeting nucleolin facilitates the development of blood-tumor barrier-penetrating and glioblastoma-specific PROTACs
Hongzhen Chen, Junyi Zhao, Fang Qiu, Shiding Ying, Zhuqian Wang, Aiping Lü, Chao Liang
This paper develops PROTACs that cross the blood-tumor barrier by targeting nucleolin, showing anti-glioblastoma efficacy without toxicity.
bioRxiv · Jul 22, 2025 · PreprintCancer Biology