Cancer BiologybioRxivPreprint
Targeting nucleolin facilitates the development of blood-tumor barrier-penetrating and glioblastoma-specific PROTACs
Hongzhen Chen, Junyi Zhao, Fang Qiu…·Chao Liang
This paper develops PROTACs that cross the blood-tumor barrier by targeting nucleolin, showing anti-glioblastoma efficacy without toxicity.
DOI 10.1101/2025.07.22.666084