JAG2-related muscular dystrophy and Notch signaling dysfunction in muscle stem cells
Nam Chul Kim, Minoru Tanaka, Isabelle Draper…·Atsushi Asakura
This study investigates JAG2-related muscular dystrophy by examining the role of Notch signaling in muscle stem cells, finding that JAG2 variants disrupt both autocrine and paracrine Notch signaling, impairing muscle regeneration.