Wolfgang Hamel

The paper investigates how Parkinson’s disease affects the sensitivity of subthalamic nucleus neurons to beta-frequency cortical input, showing increased phase-locking in PD patients and frequency-specific responses in rats.

This study examines beta burst dynamics in the cortico-basal ganglia network of PD patients and rats, showing phase relationships and rhythmic activity patterns that correlate with motor impairment.

This study investigates phase-amplitude coupling (PAC) in the subthalamic nucleus of Parkinson’s disease patients and finds that spiking activity synchronizes with high-frequency oscillations during PAC, correlating with beta burst duration.

This study shows that phase-dependent electrical stimulation can suppress beta oscillations in Parkinson's patients, offering a potential therapeutic strategy.