Manfred Westphal

This study identifies high M2-TAM infiltration as an independent poor survival prognostic factor in meningiomas, overriding the beneficial effect of TILs.

The paper identifies altered CD4 T-cell immune profiles in NSCLC patients with oligo-metastatic brain disease compared to poly-metastatic disease and healthy controls.

The paper identifies an epigenetic neural signature in glioblastoma that correlates with poor prognosis and therapeutic vulnerability.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

The paper investigates how Parkinson’s disease affects the sensitivity of subthalamic nucleus neurons to beta-frequency cortical input, showing increased phase-locking in PD patients and frequency-specific responses in rats.

This study examines beta burst dynamics in the cortico-basal ganglia network of PD patients and rats, showing phase relationships and rhythmic activity patterns that correlate with motor impairment.

This study investigates phase-amplitude coupling (PAC) in the subthalamic nucleus of Parkinson’s disease patients and finds that spiking activity synchronizes with high-frequency oscillations during PAC, correlating with beta burst duration.

This study shows that phase-dependent electrical stimulation can suppress beta oscillations in Parkinson's patients, offering a potential therapeutic strategy.