Andrew Sharott

The paper describes distinct in vivo electrophysiological profiles of three subdivisions of the mediodorsal thalamus in mice, showing differences in waveform amplitude, firing rate, and burst firing.

The paper shows that brain regions use a shared ring manifold to represent time, with population activity evolving along a common trajectory to encode elapsed time through traversal speed modulation.

This study shows that dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans compared to periodic stimulation.

The paper identifies higher-order thalamus as a critical node in schizophrenia pathophysiology, showing that restoring its activity can normalize connected brain regions.

This study uses closed-loop optogenetic stimulation to modulate theta and gamma oscillations in the motor cortex of mice, showing phase-dependent effects based on neuron type and stimulation protocol.

This paper introduces a clinical-grade neurostimulation implant that adapts its therapy based on time-of-day to improve closed-loop treatment of neurological disorders.

This study uses closed-loop tACS to enhance beta ERS during motor tasks, improving motor adaptation retention.

The paper maps pallidostriatal connectivity in mice, showing distinct innervation patterns of striatal neuron subpopulations by different pallidal neuron types.

This study uses dual-site beta tACS over primary motor cortices during bimanual coordination to modulate functional connectivity, finding altered connectivity but no behavioral changes.

The paper validates a mathematical model's predictions about neuronal population responses to phase-locked stimulation using ECoG data from Parkinsonian rats.

The paper shows that reward expectations during goal-directed reaching are encoded in distributed neural population dynamics across brain regions.

This study shows that dentate spikes (DSs) during sleep reactivate memory-related neuronal patterns, supporting flexible memory, and are distinct from sharp-wave ripples (SWRs) in their structure and function.

The paper shows that forming a robust memory restricts hippocampal coactivity, impairing flexible memory formation, and that optogenetic suppression during robust memory formation restores flexibility.

The paper identifies multiple spatially discrete beta ensembles in parkinsonian cortico-basal ganglia networks, showing they form functionally connected clusters of neurons.

The paper investigates how reward, effort, and choice are encoded hierarchically across the cortex and basal ganglia during cost-benefit decisions in rats.

This study investigates the aperiodic exponent of subthalamic field potentials in Parkinsonism across species, finding it reflects excitation/inhibition balance and could be a biomarker for adaptive deep brain stimulation.

This paper demonstrates how connectivity in the cortico-basal-ganglia circuit influences beta oscillations and shows that phase-locked stimulation can modulate these oscillations based on network state.

This study investigates thalamic dysrhythmia in Parkinsonism by comparing activity in dopamine-intact and 6-OHDA-lesioned rats, finding zone-selective abnormalities in the basal ganglia-recipient zone.

This study develops a closed-loop brain stimulation algorithm in parkinsonian rats that modulates beta oscillations by synchronizing stimulation with cortical activity cycles, leading to sustained changes in oscillation amplitude and locomotion.

The paper investigates how Parkinson’s disease affects the sensitivity of subthalamic nucleus neurons to beta-frequency cortical input, showing increased phase-locking in PD patients and frequency-specific responses in rats.

This study demonstrates a system for phase-dependent closed-loop modulation of neural oscillations in Parkinson's disease, showing that stimulation at specific phases can suppress or amplify beta-band oscillations.

The paper identifies distinct neural progenitor pools in the LGE that generate diverse striatal spiny projection neurons with different properties and circuit integration.

This study examines beta burst dynamics in the cortico-basal ganglia network of PD patients and rats, showing phase relationships and rhythmic activity patterns that correlate with motor impairment.

This study investigates the neural mechanisms underlying transitions in cortical beta power in Parkinsonian rats using dynamic causal modeling and identifies key thalamocortical coupling patterns.

This study investigates phase-amplitude coupling (PAC) in the subthalamic nucleus of Parkinson’s disease patients and finds that spiking activity synchronizes with high-frequency oscillations during PAC, correlating with beta burst duration.

This study shows that phase-dependent electrical stimulation can suppress beta oscillations in Parkinson's patients, offering a potential therapeutic strategy.

The paper investigates changes in directed connectivity within cortico-basal ganglia networks in Parkinsonian rats following dopamine depletion, finding dopamine-dependent beta and gamma rhythms and altered connections.