Author

James E. Samuel

Texas A&M Health Science CenterORCID 0000-0002-3896-8581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Erin J. van SchaikiD· 2 shared Alycia P. FratzkeiD· 1 shared Andrew Phillip WestiD· 1 shared Anna Busbee· 1 shared Aryashree ArunimaiD· 1 shared Bobby Dow· 1 shared Jennifer E. DumaineiD· 1 shared Joseph A. SzuleiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Erin J. van SchaikORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Coxiella burnetii type IVB secretion system modulates TLR3/TRIF-dependent NF-κB and IRF responses during infection

Saugata Mahapatra, Aryashree Arunima, Anna Busbee, Jennifer E. Dumaine, Lauren W. Stranahan, Ricardo A. Zeledon, Bobby Dow, Samantha Butler, Sabrina Clark, Andrew Phillip West, Erin J. van Schaik, James E. Samuel

This study shows Coxiella burnetii uses its type IVB secretion system to suppress TLR3/TRIF signaling, inhibiting NF-κB and IRF responses during infection.

bioRxiv · Sep 24, 2026 · PreprintMicrobiology

Molecular Mechanisms of Coxiella burnetii Formalin Fixed Cellular Vaccine Reactogenicity Evaluated in an Established Mouse Model

Alycia P. Fratzke, Joseph A. Szule, S. M. Butler, Erin J. van Schaik, James E. Samuel

This study identifies the cellular and molecular mechanisms underlying reactogenicity of the Coxiella burnetii vaccine in a mouse model, showing the role of antibodies, CD4+ T cells, and IFN-gamma.

Infection and Immunity · Oct 2, 2024Peer-reviewedImmunology