Coxiella burnetii type IVB secretion system modulates TLR3/TRIF-dependent NF-κB and IRF responses during infection
Saugata Mahapatra, Aryashree Arunima, Anna Busbee, Jennifer E. Dumaine, Lauren W. Stranahan, Ricardo A. Zeledon, Bobby Dow, Samantha Butler, Sabrina Clark, Andrew Phillip West, Erin J. van Schaik, James E. Samuel
This study shows Coxiella burnetii uses its type IVB secretion system to suppress TLR3/TRIF signaling, inhibiting NF-κB and IRF responses during infection.
bioRxiv · Sep 24, 2026 · PreprintMicrobiology